Last updated: 2021-09-14

Checks: 2 0

Knit directory: proxyMR/

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Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.


These are the previous versions of the repository in which changes were made to the R Markdown (analysis/notes.Rmd) and HTML (docs/notes.html) files. If you've configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File Version Author Date Message
Rmd f8ee7b4 jennysjaarda 2021-09-14 add a few Rmd notebooks

1 Meta-analysis across sexes

There are two inputs into MR:

  1. SNP/exposure effects.
  2. SNP/outcome effects.

If we want to perform a MR between exposure \(X\) and outcome \(Y\) comprising both sexes, we have three options:

  1. Use joint GWAS statistics (i.e. \(X \sim G\) is run in sexes combined, adjusted for sex).
  2. Use sex-specific GWAS statistics and then meta-analyze before running the MR.
  3. Use sex-specific GWAS statistics and then meta-analyze the after running the MR.

In other words, there are three options for pooling the data:

  1. At the selection of subgroup for GWAS analysis level.
  2. At the SNP/exposure and SNP/outcome level.
  3. At the MR level.